27 research outputs found
Immunotherapy of Head and Neck Cancer: Current and Future Considerations
Patients with head and neck squamous cell carcinoma (HNSCC) are at considerable risk for death, with 5-year relative survival rates of approximately 60%. The profound multifaceted deficiencies in cell-mediated immunity that persist in most patients after treatment may be related to the high rates of treatment failure and second primary malignancies. Radiotherapy and chemoradiotherapy commonly have severe acute and long-term side effects on immune responses. The development of immunotherapies reflects growing awareness that certain immune system deficiencies specific to HNSCC and some other cancers may contribute to the poor long-term outcomes. Systemic cell-mediated immunotherapy is intended to activate the entire immune system and mount a systemic and/or locoregional antitumor response. The delivery of cytokines, either by single cytokines, for example, interleukin-2, interleukin-12, interferon-γ, interferon-α, or by a biologic mix of multiple cytokines, such as IRX-2, may result in tumor rejection and durable immune responses. Targeted immunotherapy makes use of monoclonal antibodies or vaccines. All immunotherapies for HNSCC except cetuximab remain investigational, but a number of agents whose efficacy and tolerability are promising have entered phase 2 or phase 3 development
Free microvascular tissue transfer for the reconstruction of midfacial defects in oncological patients
This study reviews our experience with free microvascular tissue transfer for the repair of midfacial defects in surgical oncology. From 2000 to 2008, eight patients with maxillectomy defects were immediately reconstructed using free flaps. Their clinical charts were retrospectively reviewed to record demographic data, ablative and reconstructive procedures, complications and outcome. Free tissue transfer was successful in all patients, giving an overall success rate of 100%. The mean follow-up time was 4 to 101 months (mr: 43.8). Three patients died from the disease giving a patient mortality of 30%, while five patients are alive, free of disease and back to their normal daily activities. The restoration of function and improvement of patients? quality of life was a common feature in all our reconstructions. The development of free tissue transfer has made surgical treatment of oncological patients with maxillectomy defects previously considered inoperable possible, improving at the same time their quality of life
Infected lingual osseous choristoma : report of a case and review of the literature
Osseous choristoma is a rare, benign lesion of the oral cavity occurring usually in the tongue. It appears as a tumorous mass of normal bony structure with mature cells in an ectopic position. The case of a 72 years Caucasian male is presented and analyzed along with 52 similar cases reported in the English literature between 1967 and 2007. Lingual choristoma shows a female predilection, whereas the commonest anatomic location is the posterior third of the tongue, occurring at or close to the foramen caecum and the circumvallate papillae. Histologically the lesions show signs of a well-circumscribed mass of vital bone located under the surface oral epithelium. Some lesions represent developmental malformations, whereas others may be reactive lesions after trauma or chronic irritation. Treatment of lingual osseous choristoma consists of simple excision
Endoscope-Assisted Submandibular Sialadenectomy: A Review of Outcomes, Complications, and Ethical Concerns
Objectives: To review outcomes and complications of endoscope-assisted submandibular sialadenectomy (EASS) and to analyze this innovative technique with regard to ethical issues. Methods: We used a systematic review study design to identify clinical studies on EASS, published in English, French, German, and Thai. The last electronic search was conducted in September 2009. We checked the bibliographies of the identified articles, relevant local journals, and congress abstracts. Publications were further assessed and assigned their respective levels of evidence. We also investigated reporting on human subject protection, conflicts of interest, funding support, and commercial relationships. Results: Five case series reporting a total of 28 patients met the inclusion criteria. There was no need of recourse to open surgery. All of the authors claimed satisfactory cosmetic results. Complications were uncommon. However, no controlled trial was available, and outcome measures varied between studies. Human subject protection and funding sources were mentioned in only 2 articles. Commercial relationships and conflicts of interest could not be identified. Conclusions: All of the reports favor outcomes of EASS. However, their level of evidence is low, and the superiority of this procedure over the conventional surgery remains unknown. The success of this procedure should not be overemphasized in information for consent and mislead surgeons to begin it without adequate training and elaborate environment. The lack of ethical documentation creates a high degree of suspicion of the studies
Search for a Scalar Bottom Quark with Mass 3.5-4.5 GeV/
We report on a search for a supersymmetric meson with mass
between 3.5 and 4.5 GeV/ using 4.52 of integrated
luminosity produced at GeV, just below the threshold, and collected with the CLEO detector. We find no evidence
for a light scalar bottom quark.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Search for Top Squark Pair Production in the Dielectron Channel
This report describes the first search for top squark pair production in the
channel stop_1 stopbar_1 -> b bbar chargino_1 chargino_1 -> ee+jets+MEt using
74.9 +- 8.9 pb^-1 of data collected using the D0 detector. A 95% confidence
level upper limit on sigma*B is presented. The limit is above the theoretical
expectation for sigma*B for this process, but does show the sensitivity of the
current D0 data set to a particular topology for new physics.Comment: Five pages, including three figures, submitted to PRD Brief Report
Second Generation Leptoquark Search in p\bar{p} Collisions at = 1.8 TeV
We report on a search for second generation leptoquarks with the D\O\
detector at the Fermilab Tevatron collider at = 1.8 TeV.
This search is based on 12.7 pb of data. Second generation leptoquarks
are assumed to be produced in pairs and to decay into a muon and quark with
branching ratio or to neutrino and quark with branching ratio
. We obtain cross section times branching ratio limits as a function
of leptoquark mass and set a lower limit on the leptoquark mass of 111
GeV/c for and 89 GeV/c for at the 95%\
confidence level.Comment: 18 pages, FERMILAB-PUB-95/185-
Hadronic contributions to of the leptons and to the effective fine structure constant
The hadronic contributions to the anomalous magnetic moments of the leptons
and to the effective fine structure constant at the Z-mass are reevaluated
using all presently available data.Comment: 36 pages, 11 Postscript figures, available at
ftp://129.129.40.58/pub/preprints/vapogm2.ps.g
Contemporary management of cancer of the oral cavity
Oral cancer represents a common entity comprising a third of all head and neck malignant tumors. The options for curative treatment of oral cavity cancer have not changed significantly in the last three decades; however, the work up, the approach to surveillance, and the options for reconstruction have evolved significantly. Because of the profound functional and cosmetic importance of the oral cavity, management of oral cavity cancers requires a thorough understanding of disease progression, approaches to management and options for reconstruction. The purpose of this review is to discuss the most current management options for oral cavity cancers
Subjet Multiplicity of Gluon and Quark Jets Reconstructed with the Algorithm in Collisions
The D0 Collaboration has studied for the first time the properties of
hadron-collider jets reconstructed with a successive-combination algorithm
based on relative transverse momenta () of energy clusters. Using
the standard value D = 1.0 of the jet-separation parameter in the
algorithm, we find that the of such jets is higher than the of
matched jets reconstructed with cones of radius R = 0.7, by about 5 (8) GeV at
(240) GeV. To examine internal jet structure, the
algorithm is applied within D = 0.5 jets to resolve any subjets. The
multiplicity of subjets in jet samples at GeV and 630 GeV is
extracted separately for gluons () and quarks (), and the ratio of
average subjet multiplicities in gluon and quark jets is measured as . This ratio
is in agreement with the expectations from the HERWIG Monte Carlo event
generator and a resummation calculation, and with observations in
annihilations, and is close to the naive prediction for the ratio of color
charges of .Comment: Submitted to Phys.Rev.D. 24 pages, 31 figures. Updated references,
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